| Rank | City | Population | Province | 
|---|---|---|---|
| 1 | Panama City | 880,691 | Panamá | 
| 2 | San Miguelito | 315,019 | Panamá | 
| 3 | Tocumen | 103,177 | Panamá | 
| 4 | David | 89,442 | Chiriquí | 
| 5 | Las Cumbres | 89,000 | Panamá | 
| 6 | Colón | 78,000 | Colón | 
| 7 | La Chorrera | 68,896 | West Panamá | 
| 8 | Pacora | 52,494 | Panamá | 
| 9 | Santiago de Veraguas | 50,877 | Veraguas | 
| 10 | Chitré | 46,191 | Herrera | 
| 11 | Arraiján | 41,041 | West Panamá | 
| 12 | Vista Alegre | 41,000 | West Panamá | 
| 13 | Chilibre | 37,340 | Colón | 
| 14 | Cativá | 34,500 | Colón | 
| 15 | Nuevo Arraiján | 27,000 | West Panamá | 
| 16 | Changuinola | 24,420 | Bocas del Toro | 
| 17 | Alcalde Díaz | 22,000 | Panamá | 
| 18 | Penonomé | 21,748 | Coclé | 
| 19 | La Cabima | 21,200 | Panamá | 
| 20 | Puerto Armuelles | 19,753 | Chiriquí |