| Rank | City | Department | Population |
|---|---|---|---|
| 1 | Managua | Managua Department | 1,028,808 |
| 2 | León | León Department | 201,100 |
| 3 | Masaya | Masaya Department | 166,588 |
| 4 | Matagalpa | Matagalpa Department | 150,643 |
| 5 | Chinandega | Chinandega Department | 133,361 |
| 6 | Granada | Granada Department | 123,697 |
| 7 | Jinotega | Jinotega Department | 123.548 |
| 8 | Esteli | Esteli Department | 122,924 |
